Afiliation: Institute of Biotechnology – BIOCEV, Czech Academy of Sciences, Průmyslová 595, 252 50 Vestec, Prague-West, Czech Republic
Research Interests:
Interaction and recognition of biomolecules, non-bonding interactions
Hydration and solvation of biomolecules (proteins and nucleic acids)
Molecular modeling and simulations (molecular dynamics, enhanced sampling methods)
Computational studies of enzymatic catalysis
Protein engineering and design
Five selected papers
L. Biedermannova, B. Schneider: Structure of the ordered hydration of amino acids in proteins: analysis of crystal structures. Acta Crystallogr. D 2015, 71(11) 2192-2202.
J. Cerny, L. Biedermannova, P. Mikulecky, J. Zahradnik, T. Charnavets, P. Sebo, B. Schneider: Redesigning protein cavities as a strategy for increasing affinity in protein-protein interaction. Interferon-γ receptor 1 as a model. BioMed Research International 2015, ID 716945.
A.V. Malkov, S. Stoncius, M. Bell, F. Castelluzzo, P. Ramirez-Lopez, L. Biedermannova, V. Langer, L. Rulisek, P. Kocovsky: Mechanistic dichotomy in the asymmetric allylation of aldehydes with allyltrichlorosilanes catalyzed by chiral pyridine N-oxides. Chem. Eur. J. 2013 19(28), 9167-9185.
E. Chovancova, A. Pavelka, P. Benes, O. Strnad, J. Brezovsky, B. Kozlikova, A. Gora, V. Sustr, M. Klvana, P. Medek, L. Biedermannova, J. Sochor, J. Damborsky: CAVER 3.0: a tool for the analysis of transport pathways in dynamic protein structures. PLoS Comp. Biol. 2012, 8, e1002708.
L. Biedermannova, Z. Prokop, A. Gora, E. Chovancova, M. Kovacs, J. Damborsky, R.C. Wade: A single mutation in a tunnel to the active site changes the mechanism and kinetics of product release in haloalkane dehalogenase LinB. J. Biol. Chem. 2012, 287(34) 29062-29074.