VIII Discussions 2010

Institute of Biotechnology AS CR
Czech & Slovak Crystallographic Association and
Institute of Physical Biology, University of Southern Bohemia, Ceske Budejovice

VIIIth Discussions in Structural Molecular Biology

Nove Hrady, 18 – 20 March 2010

Program of the Eighth “Discussions”
Thursday, March 18

12:00 – 13:15 Registration

13:30 – 14:30 Open forum about the future of structural biology in Europe. Chairperson Vladimir Sklenář

Introduction: J. Dohnálek: INSTRUCT – An Integrated Structural Biology Infrastructure for Europe
Do we need formal professional organization?
Meeting will be held in the Czech and/or Slovak languages. Its preliminary program and draft of the by-laws of the proposed National Forum for Structural Biology, NFSB, can be downloaded.
14:30 – 15:00 Coffee break

15:00 – 15:05 Opening the Conference

15:05 – 17:05 Session I, chairperson Bohdan Schneider

Z. Tošner: Solid-state NMR of biological samples
P. Srb: Dynamical analysis of WT M-PMV matrix protein and its single point mutant R55F with respect to their different oligomerization properties
J. Prchal: Interaction of the M-PMV matrix protein with phosphatidylinositol bisphosphate
V. Kopecký: Structure differences between protein crystals and solution structures monitored by Raman spectroscopy – case study of PsbP protein
V. Andrushchenko: Structure of guanine octamers d(G)8 determined by combination of VCD spectroscopy and theoretical computations
I. Kratochvílová: Charge transport in DNA oligonucleotieds with various base-pairing patterns
17:05 – 17:20 Coffee break

17:20 – 19:20 Session II, chairperson Jiri Damborsky

P. Jungwirth: The interface between oxidized phospholipid bilayers and aqueous solutions (*)
B. Minofar: Aqueous salt solution of organic solvents as a media for enzymatic reactions
V. Stepánková: Effect of organic solvents on structure and function of haloalkane dehalogenases
T. Mozga: Biochemical and structural characterization of novel haloalkane dehalogenase DbeA from Bradyrhizobium elkani USDA94 possesing two halide-binding sites
R. Ettrich: Was binding of free amino acids an early innovation in the evolution of allostery? (*)
19:30 – 22:30 Banquet

Friday, March 19
7:00 – 8:45 Breakfast

9:00 – 10:30 Lecture Session III, chairperson Tomás Obšil

J. Koca: Computational methods as a component of modern structural biology (*)
V. Spiwok: Free Energy Modelling of Substrate Distortion in the Enzyme Active Site: An Example of Influenza Neuraminidase
R. Svobodová-Vareková: SiteBinder – software tool for superimposing multiple structural motives
J. Cerný: Improving protein binding, in silico approach
10:30 – 10:50 Coffee break

10:50 – 12:10 Session IV, chairperson Jaroslav Koca

L. Benda: Computational analysis of the stabilization effects in successive U-Hg-U base pairs
C. M. Ionescu: Fast methods of atomic charge calculation: parameterization of EEM for applicability to metal containing proteins
J. Alán: Employment of free energy calculations to estimation of carbohydrates affinities towards PA-IIL superfamily lectins
I. Barák: Molecular and structural mechanisms of cell division site recognition in Bacillus subtilis (*)
12:10 – 13:45 Lunch

14:00 – 16:00 Lecture Session V, chairperson Jan Dohnalek

T. Obsil: Structure of the 14-3-3/FOXO4 complex derived from the fluorescence spectroscopy data
K. Procházková: Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites
P. Mader: Human carbonic anhydrase complexes with isoquinoline inhibitors
D. Kopecný: Structural analysis of plant aminoaldehyde dehydrogenases
J. Wolfová: Defining structural features of the family of tetrameric flavoproteins WrbA
T. Klumpler: Solving phase problem using a Se-Met derivative of the flavoenzyme NAD(P)H:acceptor oxidoreductase (FerB)
16:00 – 16:30 Coffee break

16:30 – 18:20 Lecture Session VI, chairperson Rudi Ettrich

B. Schneider: Bioinformatic analyses of the first solvation shell of nucleic acids (*)
J. Hasek: Using the Cambridge Structure Database of Organic and Organometalic Compounds in Structure Biology
M. Kuba: MetaCentrum – On the Way from Distributed Computing to Cyber Infrastructure for Research (*)
D. Stys: Three dimensional information structure of living cell fate (*)
18:30 – 19:30 Dinner

19:45 – 21:00 First plenary meeting of NFSB. Chairperson Bohdan Schneider

Meeting will be held in the Czech and/or Slovak languages
Organization of the NFSB, National forum for structural biology,
Legal framework
Election of the NFSB committee
21:00 – 23:00 Poster session

Saturday, March 20
7:00 – 8:45 Breakfast

9:00 – 10:20 Session VII, chairperson Richard Stefl

V. Motácková: Structure and dynamics of RNA polymerase delta subunit from Bacillus subtilis determined by NMR spectroscopy (*)
F. Hóbor: The role of Nrd1-Nab3 complex in transcription termination
K. Kubícek: Structural insights into recruitment and dissociation of RNA polymerase II termination factors (*)
10:20 – 10:45 Coffee break

10:45 – 11:55 Session VII, chairperson Jiri Vondrasek

V. Veverka: Structural insight into regulation of the Wnt/b-catenin signalling pathway by sclerostin: implications for osteoporosis treatments (*)
J. Houser: High-affinity lectins from pathogens: the potential targets for antiadhesive drug design
R. Dvorský: From Structural Biology to the Drugs against Inflammatory Bowl Diseases
11:55 – 11:59 Concluding remarks

12:15 – 14:00 Lunch

Thirty minute talks are labeled by an asterix, (*), other talks have a limit of 20 minutes.
All times include discussion and will be strictly observed.