Institute of Biotechnology AS CR
Institute of Nanobiology and Structural Biology, GCRC AS CR
South Bohemian University in České Budějovice
Czech Society for Structural Biology
proudly organize
XIII Discussions in Structural Molecular Biology
Nové Hrady, Thursday March 19 – Saturday March 21 2015
Program
The whole program takes place at Nový zámek.
All talks labeled (30′) take 30 minutes, all other take 20 minutes. These times will be observed and include discussion, leave at least 5 minutes to your colleagegues!
Thursday, March 19
10:30 12:30
Registration at Nový Zámek
12:30 13:30
Accommodation
Please note that the conference starts at 14:00
Opening of the XIII Discussions by Rector of South Bohemian University, Prof. Libor Grubhoffer
14:00 15:40 Session 1
Chairperson: Tomáš Obšil
Jiri Brynda Carborane-Based Inhibitors of Carbonic Anhydrases and their Potential for Cancer Therapy
Ales Hnizda Structural basis for hyperactivity of cN-II mutants
Jana Škerlová The unique mechanics of bacterial repressor DeoR: a structural study
Adriana Baumlová The crystal structure of the phosphatidylinositol 4-kinase IIα
Vladena Bauerová-Hlinková Insights into the structure of the human RyR2 N‑terminal region and its mutations responsible for cardiac arrhythmias
15:40 16:00
Coffee break
16:00 17:20 Session 2
Chairperson: Jan Dohnálek
Mariusz Jaskólski Modulated protein crystal structure with 28 molecules in the asymmetric unit
Kay Diederichs CC* – Linking crystallographic model and data quality (30)
Sergei Kalynych Structural studies of human parechovirus 1 (30)
17:20 17:35
Short break
17:35 18:35 Session 3
Chairperson: Miroslav Kloz
Tereza Skálová Structure of LLT1, a ligand for human NKR-P1, and its variability under various conditions
Jost Ludwig A refined atomic scale model of the yeast K+-translocation protein Trk1
Janos Hajdu The European XFEL and its potentials in structural biology
19:00 21:00
Dinner
Friday, March 20
7:30 8:45
Breakfast
9:00 10:20 Session 4
Chairperson: Jiří Vondrášek
Jaroslav Koca Structural Bioinformatics – a Bridge between Structural Biology and Bioinformatics
Vladimir Sychrovsky The activation of N-glycosidic bond cleavage operated by hOGG1 enzyme can be specifically controlled by electrophilicity/nucleophilicity
Lada Biedermannová Hydration of amino acid residues in proteins: what can we learn from data mining?
David Jakubec Large-scale quantitative assessment of binding preferences in protein – nucleic acid complexes
10:20 10:40
Coffee break + observation of a partial solar eclipse
10:40 12:20 Session 5
Chairperson: Jaroslav Koča
Alan Kádek Structural dynamics of WrbA protein probed by mass spectrometry
Petr Man Hydrogen/deuterium exchange: moving from easy proteins to real life stories
Tomáš Náhlík Description of Algorithm for Analysis and 3D Reconstruction of Living Cell Inner Structures from Bright-Field Microscopy
Lucie Bednarova Spectroscopic studies of phosphoenolpyruvate carboxykinase from Mycobacterium tuberculosis
Dalibor Stys
Measurement in biological systems
Vladimír Sklenář Brief information about the Czech Infrastructure for Integrative Structural Biology, CIISB
12:30 13:45
Lunch
14:00 15:40 Session 6
Chairperson: Bohdan Schneider
Piotr Wardega Quantitative analysis of biomolecular interactions with Microscale Thermophoresis (MST)
Dhiraj Sinha Interdomain interaction in the motor subunit of the type I restriction-modification system EcoR124I and their functional relevance
Tatsiana Charnavets Repetitive extragenic Palindroms from Haemophilus Parasuis and their associated transposase RAYT
Miroslav Kloz Coherent Raman spectroscopy – nonivasive structural tool for time resolved structures
Salome Kylarova Structural studies of ASK1-TBD:TRX1 complex by fluorescence spectroscopy and SAXS
Tomas Klumpler Biological Small Angle X-ray Scattering at CEITEC-MU
15:40 16:00
Coffee break
16:00 18:00 Session 7
Chairperson: Jindřich Hašek
Irena Kratochvilova Theoretical and Experimental Study of Charge Transfer Through DNA: Impact of Mercury Mediated T-Hg-T Base Pair
Babak Minofar The interactions of soil natural organic matter (NOM) and polycyclic aromatic hydrocarbon (PAH) with biological interfaces studied by MD simulations
Renata Rychtarikova Analysis of living cell 3D inner structures from high-resolution bright-field microscopy
Hedi Hegyi Enhancer-promoter interaction facilitated by transiently forming G-quadruplexes
Charles Sabin Using Non-Crystallographic-Symmetry to solve the structure of a perfect merohedral twin crystal of Aichi virus (AiV)
Daniel Nemecek Molecular Architecture of Encapsulin Nanocompartments
18:15 19:30
Dinner
19:30 20:45
General Assembly of the Czech Society for Structural Biology. Meeting will be held in the Czech and/or Slovak languages
Program Valného shromáždění ČSSB 1. Volba zpisovatele
2. Schválení programu
3. Výroční zpráva Rady ČSSB o činnosti a hospodaření
4. Schválení výroční zprávy Rady ČSSB o činnosti a hospodaření
5. Zpráva revizní komise
6. Stav infrastrukturních center se vztahem ke strukturní biologii
7. Návrh úprav stávajících stanov ČSSB podle nového Občanského zákoníku, diskuze
8. Hlasování – schválení nové verze stanov ČSSB
9. Různé
10. Volby Rady ČSSB (zajistí volební komise)
11. Diskuse, úkoly pro novou Radu
21:00 23:00 Poster session Presented posters are listed below
Saturday, March 21
7:30 8:45
Breakfast
9:00 10:30 Session 8
Chairperson: Michaela Wimmerová
Radovan Dvorsky Miracle of multi-domain proteins: a case study of ROCK Kinase
Petra Babková Understanding structure-function relationships of haloalkane dehalogenaseS by ancestral sequence reconstruction
Zora Nováková Structural characterization of interactions between human glutamate carboxypeptidase II and hydroxamate-based inhibitors
Ladislav Bumba Probing metal-ion-assisted π−π interaction in self-processing module of FrpC protein
Tomasz Kabzinski Structural basis for transcription termination coupled to RNA processing/degradation (30)
10:30 10:50
Coffee break
10:50 12:40 Session 9
Chairperson: Lukáš Žídek
Klaudia Šarmírová Functional analysis of a novel haloalkane dehalogenase DsvA isolated from thermophilic bacterium Saccharomonospora viridis DSM 4
Magdalena Krejcikova Combining NMR and Raman spectroscopy reveals structural and functional features of a new cisplatin derivative
Vojtech Kuban NMR Structural Study of Self-Processing Module
Petr Těšina LEDGF/p75 as a Target for Treatment of MLL-Dependent Lekemia and HIV Infection
Jozef Hritz Complex binding scheme between 14-3-3zeta and phosphoproteins elucidated by NMR and computational studies (30)
12:45 14:00
Lunch
Posters (presented Friday, March 20, 21 – 23 o’clock)
| First | Last | Title |
| Kristýna | Boušová | PIP2 and PIP3 interact with N-terminus region of TRPM4 channel |
| Petr | Čech | Automatic workflow for the classification of local DNA conformations |
| Jiří | Černý | Modeling of blocking of NMDA receptor channel by endogenous neurosteroids |
| Dominika | Chalupská | Mechanism of phosphatidylinositol 4-kinase IIIβ inhibition |
| Jindrich | Fanfrlik | The Semiempirical Quantum Mechanical Scoring Function for In-Silico Drug Design |
| Karla | Fejfarová | PDBCOP: PDB Comparison Program |
| Jindrich | Hasek | Receptors expressed on the natural killer cells; Review of the molecular structure data |
| Katarína | Hlat-Glembová | Identification of the Catalytic residues of glycosidases from Paenibacillus thiaminolyticus as a way to engineering of new glyco |
| Josef | Houser | Possibilities for biomacromolecular crystallization at BIC Core Facility at CEITEC, Brno |
| Dominik | Hrebík | NMR relaxation studies of receiver domain of cytokinin receptor CKI1RD mutants from Arabidopsis thaliana |
| Kristýna | Hudcová | Spectral and electrochemical analysis of miR-34a-5p |
| Adela | Jilkova | Activation route of the Schistosoma mansoni cathepsin B1 drug target |
| Michaela | Jirků | PIP2 interact with cytosolic N-terminal region of the melastatin channel TRPM1 |
| Miroslava | Kacirova | Structural characterization of phosphoprotein phosducin and its interaction with 14-3-3 |
| Radka | Končitíková | Structure-function study on plant aldehyde dehydrogenases from family 2 and family 7 |
| Miroslava | Kopecka | Structural study of the yeast enzyme neutral threhalase and its complex with the14-3-3 protein |
| David | Kopečný | Site-directed mutagenesis of two nucleoside N-ribohydrolases from maize |
| Dalibor | Kosek | Sedimentation analysis of the interaction between ASK1 and its binding partners |
| Terezia | Kovalova | Crystallographic and catalytic study of α-L-fucosidase from Paenibacillus thiaminolyticus |
| Zuzana | Kovářová | Proteolytic system of blood-feeding ticks: an update on protein structures |
| Tomáš | Kroupa | Retroviral matrix proteins interaction with membranes |
| Monika | Krupová | Studies of Lanthanide Complexes by a Combination of Spectroscopic Methods |
| Katsiaryna | Tratsiak | Structure-functional analysis of the haloalkane dehalogenase DmxA from Marinobacter sp. ELB17 |
| Petr | Lousa | Monitoring of phosphorylation progress of tyrosine hydroxylase and interaction with 14‑3‑3zeta elucidated by NMR |
| Václav | Mareška | Role of CH/π interactions in stabilizing the protein-carbohydrate complex |
| Katarina | Muchova | Link between cytoskeleton and spore formation in Bacillus subtilis |
| Gabor | Nagy | Molecular Interactions of the 14-3-3-zeta protein |
| Iva | Nečasová | Biophysical and structural studies of a new type of transposases – RAYTs |
| Vít | Novák | Spectra Modelling Combining Molecular Dynamics and Quantum Mechanics |
| Jiří | Pavlíček | Structural and Functional Studies of Human Histone Deacetylase 6 |
| Hana | Petrokova | Inhibitory protein variants derived from an albumin-binding domain scaffold targeting human IL-23 cytokine |
| Olívia | Petrvalská | Structural analysis of the ASK1-CD:14-3-3 complex by small angle X-ray scattering |
| Tatyana | Prudnikova | Structure-functional studies of haloalkane dehalogenases |
| Jakub | Ptáček | Engineered Anticalins targeting human prostate-specific membrane antigen |
| David | Řeha | Structural characterization of NAD(P)H:quinone oxidoreductase WrbA from E. coli in complex with benzoquinone |
| Mohammadmehdi | Saberioon | Application of Multispectral Cameras for estimating Nitrogen and Grain Yield in Paddy fields |
| Tanvir | Shaikh | Integration of SPIDER workflows into Scipion for user-friendly analysis of electron microscopy data |
| Marta | Siborova | Mechanism of Staphylococcus aureus cell wall penetration by phage phi812/K1 |
| Radim | Skoupý | CryoEM reconstruction of small nucleoprotein complexes: Application to the EcoR124I restriction-modification enzyme |
| Michal | Škultéty | Theoretical study of carbonic anhydrase IX |
| Vojtech | Spiwok | Altruistic metadynamics |
| Jaroslav | Srp | A Plant-Insect Interaction in 3D |
| Jan | Stránský | Influence of phosphate ion bound to active center of TBN1 |
| Zoran | Šućur | Homology modeling of GPCR: oxytocin receptor |
| Leona | Švecová | Structure of Bilirubin oxidase from Myrothecium verrucaria with ligand in active site |
| Ekaterina | Sviridova | Crystallographic characterization of the outer memberane lipoprotein FrpD from Neisseria Meningitidis |
| Mária | Trundová | Expression of toxic recombinant proteins for structural studies in the E. coli Lemo21(DE3) expression system |
| Zorica | Ubiparip | Structural Analysis of Frog Virus 3 by Electron Microscopy and Tomography: Composition and Morphology of its Large Virion |
| Anna | Zhyrova | Phase transition approach on the interpretation of the chemical oscillation in the Belousov-Zhabotinsky reaction |
Deadline for registration and submission of abstracts was Friday February 20 2015
If still missing, please, send your abstracts as attachment in word.docx format to kuzel-at-karlov.mff.cuni.cz
Deadline for the payment is Friday March 6 2015
Abstracts of all contributions of the XIII Discussions
Photos from the conference by Bohdan Schneider, photos by Radek Kuzel.
The conference has been supported by program “Education for Competitiveness) of the Ministry of Education, Youth, and Sports of the Czech Republic, more information about the program in the Czech language are here.
Konference byla podpořena programem OP VK Ministerstva školství, mládeže a tělovýchovy. Více informací o programu lze nalézt zde.
INVESTMENTS IN EDUCATION DEVELOPMENT
Organizers of the meeting Bohdan Schneider, Radek Kužel, Ivana Kutá-Smatanová, Rudiger Ettrich, Jindřich Hašek, Jan Dohnálek