Center for Biomolecules and Complex Molecular Systems
Institute of Physical Biology, University of Southern Bohemia, České Budějovice
CASTECH, Nové Hrady association for ennoblement of science and technology
Czech and Slovak Crystallographic Association
organize
5th Discussions in Structural Molecular Biology
Program of the Meeting (March 16 – 18 2006)
Thursday, March 16
13:00 – 15:00 Registration
15:10 – 15:15 Introductory remarks
15:15 – 16:30 Lecture session I, chairman V. Sychrovský
Tomáš Obšil: Regulation by molecular interference: How 14-3-3 protein controls activity of forkhead transcription factor FOXO4
Karel Bezouška: Spectroscopy, mass spectrometry and NMR are essential tools in the production of soluble receptors of natural killer cells
Jiří Vlach: A single-point mutation of M-PMV matrix protein causes reorientation of protein domains and changes the phenotype of the virus
Zuzana Vokáčová: NMR parameters in RNA molecules and their correlation with molecular structure
16:30 – 17:00 Coffee break
17:00 – 17:45 Plenary lecture I, chairman V. Sychrovský
Bohdan Schneider: Structural Databases in Biology
18:15 – 22:30 Banquet
Friday, March 17
7:00 – 8:45 Breakfast
9:00 – 9:45 Plenary lecture III, chairman D. Štys
Rudiger Ettrich: Molecular systems biology: Molecular simulations of proteins and their complexes
9:45 – 10:15 Coffee break
10:15 – 12:00 Lecture session II, chairman D. Štys
Jan Florian: Computer Simulations of Protein Functions: Searching For the Molecular Origin of the Replication Fidelity of DNA Polymerases
Pavel Macek: Molecular dynamics study of major urinary protein-pheromone interactions: A structural model for ligand induced flexibility increase
Jiří Šebek: MD and Ab Initio Modeling of Electronic Spectra of N-methylacetamide and Peptides in Water Solutions
Peter Flecker: Molecular Modelling studies with Bowman Birk inhibitors
Michal Hušák: The use of GPU based calculations in structural biology
Patrik Florek: Bacterial programmed cell death – genetical, biochemical, and structural insight
12:15 – 14:00 Lunch
14:15 – 15:00 Plenary lecture IV, chairman B. Schneider
Jiří Šponer: Molecular simulations of RNA
15:00 – 15:30 Coffee break
15:30 – 17:15 Lecture session III, chairman B. Schneider
Matěj Lexa: The accuracy of domain boundary detection in proteins based on segment co-occurence compared to other methods
Peter Palenčár: Low-resolution crystal structure of photosystem II from Thermosynechococcus elongatus refined and studied by molecular dynamics
Jiří Brynda: From non-peptide towards non-carbon protease inhibitors: metallacarboranes as specific and potent inhibitors of HIV protease
Veronika Krejčiříková: Structural studies of galectin-4 N-terminal domain in complex with lactose
Daniel Svozil: DNA Conformational Families
17:45 – 18:45 Dinner
19:00 – 22:00 Poster session
Saturday, March 18
7:00 – 9:10 Breakfast
9:15 – 10:15 Plenary lecture V, chairman J. Brynda
Jan Dohnálek: Structure elucidation by diffraction methods – contribution to structural biology
10:15 – 10:30 Coffee break
10:30 – 11:50 Lecture session IV, chairman J. Damborský
Zbyněk Prokop: Discovery of Stereoselective Haloalkane Dehalogenase: New Tool for Assymetric Synthesis
Tomáš Mozga: Structure-enantioselectivity relationships of haloalkane dehalogenases
Radka Chaloupková: Physical variables as a control of enzyme stereoselectivity
Táňa Chrobáková: Engineering of enantioselective haloalkane dehalogenase by cumulative mutagenesis
Martin Klvana: Modelling of Product Release and Identification of Export Routes in Haloalkane Dehalogenase DhaA
11:50 – 12:15 Peter Šebo: Information about prospective Biochnological Institute of the AS CR
12:15 – 12:20 Concluding remarks
12:30 – 14:00 Lunch