1st Structural Biology Club of the Czech Society for Structural Biology
31 March 2021, 13:00
with the following scientific talks kindly delivered by our guests:
Structure‐assisted design of enzyme inhibitors
Presented by Pavlína Maloy Řezáčová, Institute of Organic Chemistry and Biochemistry and Institute of Molecular Genetics of the Czech Academy of Sciences, Prague
Structure‐assisted ligand design, a method used as an alternative to screening random compounds, is the process of identifying new drugs through rational design of molecules based on knowledge of the structure of their biological target. Enzymes involved in pathologies are good targets for rational design. Enzymes usually have a well‐defined active site to bind substrates, and many have allosteric sites that bind regulators and these sites can be targeted by small molecules that mimic the structure of the substrate or regulator. Results of structure‐assisted design of inhibitors targeting human carbonic anhydrase will be presented.
Structure and function of bacterial nanotubes
Presented by Libor Krásný, Institute of Microbiology of the Czech Academy of Sciences, Prague
Bacterial nanotubes are membranous structures that were reported to extend from cells and even connect two cells, serving as channels for exchange of cytoplasmic contents, including nonconjugative plasmids. Here, we explore the genetic determinants of this phenomenon, characterize their structure, and define the mechanism by which they emerge. Contrary to previous beliefs, we show that they are formed after cell death, and are a manifestation of the final cell disintegration.
Moderator: Jan Dohnálek, Institute of Biotechnology, Czech Academy of Sciences, Vestec
Please, join us on this Zoom link (join 5‐10 minutes before the beginning)
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Meeting ID: 938 4416 2846