4th Structural Biology Club of the Czech Society for Structural Biology
30 June 2021, 1 pm
with the following scientific talks kindly delivered by our guests:
How viruses escape the innate immunity: Role of RNA methylation
Presented by Evžen Bouřa, Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague
To be able to successfully reproduce in host cells, viruses must evade host immunity including the innate antiviral immunity that recognizes so called pathogen associated molecular patterns (PAMPs). Importantly, in the case of RNA viruses one of them is double-stranded RNA and/or 5′-ppp-RNA. Several viral groups including coronaviruses and flaviviruses developed a strategy based on their RNA methylation so the viral RNA would look the same as human RNA. The enzymes responsible are termed methyltransferases (MTases) and this talk will be focused on their structure and inhibitor design.
Protein interactions in the late phase of the life cycle of selected RNA viruses
Presented by Tomáš Ruml, University of Chemistry and Technology, Prague
RNA viruses are the cause of serious pandemic diseases. Despite long-term research activities on viruses such as HIV, dengue and SARS, understanding of their structures and life cycles is still incomplete. Therefore, continuous research into the structures and interactions of viral proteins and their interactions, either with each other or with cell membranes, is necessary to design new therapeutic approaches. The results of functions, structures and interactions of proteins, their complexes and particles of the above viruses will be presented.
Moderator: Vladimír Sklenář, CEITEC, Masaryk University
Please, join us on this Zoom link (join 5‐10 minutes before the beginning)
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Meeting ID: 938 4416 2846