Category: News

We are glad to inform you that we are going to organize short minisymposium named “New Trends in BioScience together with NanoTemper workshop”. The minisymposium is organized to acquaint participants with news in the field of structural biochemistry and biomedicine. Emphasis is placed on new and rapidly increasing techniques and the possibility of applying new knowledge into practice. The symposium will allow participants to test their own samples by taking part in the NanoTemper WS, which is scheduled for second day.

Date: October 10-11, 2019

Place: Building C, Faculty of Science, Uni of South Bohemia in Ceske Budejovice

Registration: until September 20^th, 2019

All information and registration at www.xray.cz/newtrends

If you plan to participate at the NanoTemper WS and try to measure your own samples, please read “NanoTemper files” on the webpage and follow instruction there.

Ivana KS and Frantisek V
symposium organizers

List of lectures:

Cristales: a world to discover (opening of exhibition)
Structure-based drug design (Pavlína Řezáčová)
Protein engineering (Radka Chaloupková)
How the cell knows where to divide? (Imrich Barák)
Structural basis for pharmacological reactivation of p53 tumorigenic mutants (Oksana Degtjarik)
Structural analysis of macromolecular complexes by single-particle cryo-electron microscopy (Iulia Iermak)
Application of cryo-electron tomography to study functions of protein complexes (Matthias Pöge)
Cell shape formation controlled by cytoskeleton (Naoko Mizuno)
TBA (Christian Biertuempfel)
Bioinformatic analysis of CE16 acetylesterases (Ľubica Urbániková)
Phase separation and formation of membrane-less organelles in cells (Roman Tůma)
Nanostructured surfaces for advanced biomedical applications (Vít Straňák)
Introduction to NanoTemper Solutions for Structural Biology (Pawel Kania, Malgorzata Poczopko)
25th IUCr congress in 2020 in Prague (Radomír Kužel)

NanoTemper MST & nanoDSF Workshop
Seminar: Interaction analysis with MicroScale Thermophoresis (MST) (Malgorzata Poczopko)
Protein stability and quality measurements with nanoDSF (Pawel Kania)
Hands-on session (MST and nanoDSF)

Dates: October 8–10, 2019

Venue: Institute of Biotechnology of the Czech Academy of Sciences, Research centre Biocev, Prumyslova 595, 25250 Vestec near Prague, Czech Republic

Aim:The course will be focused on the growing need to combine computational tools in structural biology projects. The main aims are in providing deeper insights in the computational approaches for selected techniques and then to build on the good foundations and cover also integration of data coming from various structural approaches, e.g. mass spec, NMR and other restraints used in structural analysis, together with SAXS envelopes and cryoEM maps applied in and with crystallographic analysis, use of biophysics to enhance/help in structure analysis, etc. Practical experience with selected structural biology techniques will be providedand tutorials on use of some computational tools will be given.

Link: http://www.ibt.cas.cz/sd/udalosti/kalendar/191008-Instruct-ERIC-workshop.html

Structural biology supplies data allowing insight into the molecular architecture of a cell at the atomic resolution. iNEXT, a consortium funded by the Horizon2020 program, offers European researchers access to a wide range of advanced structural biology technologies to study the structure and function of biological macromolecules and their assemblies.

The aim of the iNEXT workshop Integrated methodologies and approaches for structural biology is to provide a comprehensive overview of the state-of the-art progress of integrative methodologies to existing and potential users of iNEXT facilities. Nineteen prominent speakers will report on recent advances and developments in nuclear magnetic resonance (NMR), x-ray diffraction, small-angle x-ray scattering (SAXS), cryo electron microscopy and tomography (cryo-EM and cryo-ET), and computational structural biology. Applications of recently developed methodologies to elucidate structure and function of complex cellular components and molecular machineries will be presented. The workshop is open to all PhD students, postdoctoral fellows, and researchers at no cost.

http://inext-workshop-2019.ceitec.cz/

The XVI Discussions in Structural Molecular Biology and the 3rd User Meeting of CIISB will be held in Nove Hrady, South Bohemia, on 21 – 23 March 2019.

Registration will open in November. Please check this page for the preliminary program.

Jan Dohnalek, on behalf of the organization team

České vysoké učení technické v Praze, Fakulta jaderná a fyzikálně inženýrská a Česká společnost pro strukturní biologii vás zve na přednášku
prof. Kay Diederichs (Univerzita v Kostnici)
Taxonomy of errors and mistakes in X-ray crystallography
Přednáška se bude konat ve PONDĚLÍ dne 12.11.2018 od 10:00 hodin v místnosti ATRIUM v Břehové ulici (FJFI ČVUT, Břehová 7, Praha 1), po přednášce bude následovat představení programů XDS a XDSgui.
Organizační výbor: Jaroslav Bielčík (KF), Ivan Richter (KFE), Tomáš Bílý (KJR), Pavel Šťovíček (KM).

Abstract
Taxonomy of errors and mistakes in X-ray crystallography Crystallography lets us visualize the molecules of life – more than 130.000 structures in the PDB attest to that. But all that glitters is not gold. Some of the concepts developed decades ago now need revision. For example, analysis of crystallographic data quality is still somewhat fixated on values of Rmerge (also called Rsym), and the distinction between accuracy and precision, as well as indicators of unmerged data precision and those of merged data precision is only now starting to be accepted in the community.